11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …
[HTML][HTML] The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
AE Coutinho, KE Chapman - Molecular and cellular endocrinology, 2011 - Elsevier
Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …
inflammatory effects, they have been amongst the most widely used and effective treatments …
The enteric nervous system relays psychological stress to intestinal inflammation
KM Schneider, N Blank, Y Alvarez, K Thum… - Cell, 2023 - cell.com
Mental health profoundly impacts inflammatory responses in the body. This is particularly
apparent in inflammatory bowel disease (IBD), in which psychological stress is associated …
apparent in inflammatory bowel disease (IBD), in which psychological stress is associated …
Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology
FS Dhabhar - Neuroimmunomodulation, 2009 - karger.com
Stress is known to suppress immune function and increase susceptibility to infections and
cancer. Paradoxically, stress is also known to exacerbate asthma, and allergic, autoimmune …
cancer. Paradoxically, stress is also known to exacerbate asthma, and allergic, autoimmune …
Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model.
This study examined whether chronic stress impairs the immune system's capacity to
respond to hormonal signals that terminate inflammation. Fifty healthy adults were studied; …
respond to hormonal signals that terminate inflammation. Fifty healthy adults were studied; …
Microglial activation and its implications in the brain diseases
S Thameem Dheen, C Kaur… - Current medicinal …, 2007 - ingentaconnect.com
An inflammatory process in the central nervous system (CNS) is believed to play an
important role in the pathway leading to neuronal cell death in a number of …
important role in the pathway leading to neuronal cell death in a number of …
Central nervous system injury-induced immune deficiency syndrome
Infections are a leading cause of morbidity and mortality in patients with acute CNS injury. It
has recently become clear that CNS injury significantly increases susceptibility to infection …
has recently become clear that CNS injury significantly increases susceptibility to infection …
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2 …
We show that a combination of the immunosuppressive drugs, vitamin D3 and
Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vitro into …
Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vitro into …
The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression
K De Bosscher, W Vanden Berghe… - Endocrine …, 2003 - academic.oup.com
The inflammatory response is a highly regulated physiological process that is critically
important for homeostasis. A precise physiological control of inflammation allows a timely …
important for homeostasis. A precise physiological control of inflammation allows a timely …