Production and formulation of adenovirus vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing
clinical development programs for applications ranging from replacement therapy for protein …
clinical development programs for applications ranging from replacement therapy for protein …
The Adenovirus Death Protein–a small membrane protein controls cell lysis and disease
Human adenoviruses (HAdVs) cause widespread acute and persistent infections. Infections
are usually mild and controlled by humoral and cell‐based immunity. Reactivation of …
are usually mild and controlled by humoral and cell‐based immunity. Reactivation of …
Genomic DNA released by dying cells induces the maturation of APCs
Mature APCs play a key role in the induction of Ag-specific immunity. This work examines
whether genomic DNA released by dying cells provides a stimulus for APC maturation …
whether genomic DNA released by dying cells provides a stimulus for APC maturation …
Localization of adenovirus morphogenesis players, together with visualization of assembly intermediates and failed products, favor a model where assembly and …
GN Condezo, C San Martín - PLoS pathogens, 2017 - journals.plos.org
Adenovirus (AdV) morphogenesis is a complex process, many aspects of which remain
unclear. In particular, it is not settled where in the nucleus assembly and packaging occur …
unclear. In particular, it is not settled where in the nucleus assembly and packaging occur …
The NS2 proteins of parvovirus minute virus of mice are required for efficient nuclear egress of progeny virions in mouse cells
V Eichwald, L Daeffler, M Klein, J Rommelaere… - Journal of …, 2002 - Am Soc Microbiol
The small nonstructural NS2 proteins of parvovirus minute virus of mice (MVMp) were
previously shown to interact with the nuclear export receptor Crm1. We report here the …
previously shown to interact with the nuclear export receptor Crm1. We report here the …
Nuclear export of the nonenveloped parvovirus virion is directed by an unordered protein signal exposed on the capsid surface
It is uncertain whether nonenveloped karyophilic virus particles may actively traffic from the
nucleus outward. The unordered amino-terminal domain of the VP2 major structural protein …
nucleus outward. The unordered amino-terminal domain of the VP2 major structural protein …
Development of a purification process for adenovirus: controlling virus aggregation to improve the clearance of host cell DNA
JO Konz, AL Lee, JA Lewis, SL Sagar - Biotechnology progress, 2005 - Wiley Online Library
The clearance of host cell DNA is a critical goal for purification process development for
recombinant Ad5 (rAd5) based vaccines and gene therapy products. We have evaluated the …
recombinant Ad5 (rAd5) based vaccines and gene therapy products. We have evaluated the …
[HTML][HTML] Microscopy deep learning predicts virus infections and reveals mechanics of lytic-infected cells
Imaging across scales reveals disease mechanisms in organisms, tissues, and cells. Yet,
particular infection phenotypes, such as virus-induced cell lysis, have remained difficult to …
particular infection phenotypes, such as virus-induced cell lysis, have remained difficult to …
Direct antiviral effect of cycloferon (10-carboxymethyl-9-acridanone) against adenovirus type 6 in vitro
VV Zarubaev, AV Slita, VZ Krivitskaya, AK Sirotkin… - Antiviral research, 2003 - Elsevier
Adenoviruses represent a broad group of human pathogens that currently have no specific
and safe drugs for treatment. We demonstrated direct (non IFN-mediated) antiviral activity of …
and safe drugs for treatment. We demonstrated direct (non IFN-mediated) antiviral activity of …
Deep learning of virus infections reveals mechanics of lytic cells
Imaging across scales gives insight into disease mechanisms in organisms, tissues and
cells. Yet, rare infection phenotypes, such as virus-induced cell lysis have remained difficult …
cells. Yet, rare infection phenotypes, such as virus-induced cell lysis have remained difficult …