Precision medicine is part of the logical evolution of contemporary evidence-based medicine
that seeks to reduce errors and optimize outcomes when making medical decisions and …

Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …

Alzheimer's disease (AD) is the most common age-related dementia. The alteration in
metabolic characteristics determines the prognosis. Patients at risk show reduced glucose …

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …

The common I27L mutations of the hepatocyte nuclear factor-1α (HNF1A) significantly
increase the incidence of maturity-onset diabetes of the young (MODY). Hence, the …

Background Monogenic diabetes presents opportunities for precision medicine but is
underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria …

OBJECTIVE Maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as
type 1 or type 2 diabetes. Correct diagnosis may result in a change in clinical treatment and …

Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To
understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic …

Aims/hypothesis Monogenic forms of diabetes (MODY, neonatal diabetes mellitus and
syndromic forms) are rare, and affected individuals may be misclassified and treated …

More than 10% of the world's population already suffers from varying degrees of diabetes
mellitus (DM), but there is still no cure for the disease. Cardiovascular disease (CVD) is one …