The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid
leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease …

The canonical Wnt/β‐catenin pathway plays an important role in different developmental
processes through the regulation of stem cell functions. In the activation of the canonical …

Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral
heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to …

Breast cancer stem cells (BCSC) are resistant to conventional chemotherapy and
radiotherapy, which may destroy tumor masses but not all BCSC that can mediate relapses …

Nowadays, more than 90% of patients affected by chronic myeloid leukemia (CML) survive
with a good quality of life, thanks to the clinical efficacy of tyrosine kinase inhibitors (TKIs) …

Cancer has been shown to result from the sequential acquisition of genetic alterations in a
single lineage of cells. In leukemia, increasing evidence has supported the idea that this …

Methylation of histone 3 at lysine 79 (H3K79) is one of the principal mechanisms involved in
gene expression. The histone methyltransferase DOT1L, which mono-, di-and trimethylates …

Despite the success of imatinib mesylate (IM) in the early chronic phase of chronic myeloid
leukemia (CML), patients are resistant to IM and other kinase inhibitors in the later stages of …

Liver cancer stem cells (CSCs) are resistant to conventional chemotherapy and radiation,
which may destroy tumor masses, but not all liver CSCs contribute to tumor initiation …

The hallmark of CML (chronic myeloid leukaemia) is the BCR (breakpoint cluster region)–
ABL fusion gene. CML evolves through three phases, based on both clinical and …