In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

Tissue homeostasis requires maintenance of functional integrity under stress. A central
source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how …

Cells exert, sense, and respond to physical forces through an astounding diversity of
mechanisms. Here we review recently developed tools to quantify the forces generated by …

Collective cell migration has a key role during morphogenesis and during wound healing
and tissue renewal in the adult, and it is involved in cancer spreading. In addition to …

Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

Size control is fundamental in tissue development and homeostasis,. Although the role of
cell proliferation in these processes has been widely studied, the mechanisms that control …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …