Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

Low back pain (LBP), which is one of the most severe medical and social problems globally,
has affected nearly 80% of the population worldwide, and intervertebral disc degeneration …

Background Autophagy is a basic cellular homeostatic process important to cell fate
decisions under conditions of stress. Dysregulation of autophagy impacts numerous human …

Introduction Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder
of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with …

Objective. Low back pain (LBP) is one of the top three causes of disability in developed
countries, and intervertebral disc degeneration (IDD) is a major contributor to LBP. In the …

The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma
(PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance …

The mammalian target of rapamycin (mTOR) was recently identified in two structurally
distinct multiprotein complexes: mTORC1 and mTORC2. Previously, we found that …

Mesenchymal stem cells (MSCs) are widely considered for treatment of pulmonary fibrosis
based on the anti-inflammatory, antifibrotic, antiapoptotic, and regenerative properties of the …

Background and Purpose Bleomycin (BLM), one of the most common sclerosants, is often
used to treat venous malformations (VMs). The present study was designed to investigate …

Myofibroblast (MF) differentiation, marked by the de novo expression of smooth muscle α-
actin (αSMA) stress fibers, plays a central role in wound healing and its persistence is a …