Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators
Neurotransmitters and neuromodulators have a wide range of key roles throughout the
nervous system. However, their dynamics in both health and disease have been challenging …
nervous system. However, their dynamics in both health and disease have been challenging …
On what motivates us: a detailed review of intrinsic v. extrinsic motivation
Motivational processes underlie behaviors that enrich the human experience, and
impairments in motivation are commonly observed in psychiatric illness. While motivated …
impairments in motivation are commonly observed in psychiatric illness. While motivated …
[HTML][HTML] Spontaneous behaviour is structured by reinforcement without explicit reward
Spontaneous animal behaviour is built from action modules that are concatenated by the
brain into sequences,. However, the neural mechanisms that guide the composition of …
brain into sequences,. However, the neural mechanisms that guide the composition of …
Mesolimbic dopamine release conveys causal associations
Learning to predict rewards based on environmental cues is essential for survival. It is
believed that animals learn to predict rewards by updating predictions whenever the …
believed that animals learn to predict rewards by updating predictions whenever the …
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …
Spatial and temporal scales of dopamine transmission
Dopamine is a prototypical neuromodulator that controls circuit function through G protein-
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …
[HTML][HTML] Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Dopamine neurons are characterized by their response to unexpected rewards, but they
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …
[HTML][HTML] Wave-like dopamine dynamics as a mechanism for spatiotemporal credit assignment
Significant evidence supports the view that dopamine shapes learning by encoding reward
prediction errors. However, it is unknown whether striatal targets receive tailored dopamine …
prediction errors. However, it is unknown whether striatal targets receive tailored dopamine …
Navigating for reward
M Sosa, LM Giocomo - Nature Reviews Neuroscience, 2021 - nature.com
An organism's survival can depend on its ability to recall and navigate to spatial locations
associated with rewards, such as food or a home. Accumulating research has revealed that …
associated with rewards, such as food or a home. Accumulating research has revealed that …
A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning
A large body of evidence has indicated that the phasic responses of midbrain dopamine
neurons show a remarkable similarity to a type of teaching signal (temporal difference (TD) …
neurons show a remarkable similarity to a type of teaching signal (temporal difference (TD) …