FOXP3 deficiency, from the mechanisms of the disease to curative strategies

S Borna, E Meffre, R Bacchetta - Immunological Reviews, 2024 - Wiley Online Library
FOXP3 gene is a key transcription factor driving immune tolerance and its deficiency causes
immune dysregulation, polyendocrinopathy, enteropathy X‐linked syndrome (IPEX), a …

IPEX syndrome from diagnosis to cure, learning along the way

R Bacchetta, MG Roncarolo - Journal of Allergy and Clinical Immunology, 2023 - Elsevier
In the past two decades, a significant number of studies have been published describing the
molecular and clinical aspects of Immune dysregulation Polyendocrinopathy Enteropathy X …

How to choose the right treatment for membranous nephropathy

L Peritore, V Labbozzetta, V Maressa, C Casuscelli… - Medicina, 2023 - mdpi.com
Membranous nephropathy is an autoimmune disease affecting the glomeruli and is one of
the most common causes of nephrotic syndrome. In the absence of any therapy, 35% of …

The Prevalence, Characteristics, and Putative Mechanisms of Dual Antigen-Positive Membranous Nephropathy: The Underestimated Condition

T Uchida, T Oda - International Journal of Molecular Sciences, 2024 - mdpi.com
Following the discovery of podocyte phospholipase A2 receptor and thrombospondin type-1
domain-containing 7A, various potential target antigens for membranous nephropathy (MN) …

Concurrent glomerular PCDH7 deposits in PLA2R-associated membranous nephropathy

NN Fu, S Yuan, G Yang, H Li, T Wang - CEN Case Reports, 2024 - Springer
The understanding of membranous nephropathy (MN) has undergone impressive
advancements in the last 5 years, particularly due to identification of novel antigenic targets …

Diagnostic Challenges and Emerging Pathogeneses of Selected Glomerulopathies

NK Andeen, J Hou - Pediatric and Developmental Pathology, 2024 - journals.sagepub.com
Recent progress in glomerular immune complex and complement-mediated diseases have
refined diagnostic categories and informed mechanistic understanding of disease …

[HTML][HTML] 儿童原发性膜性肾病相关靶抗原及补体途径研究进展

沙亚, 白玲 - Advances in Clinical Medicine, 2023 - hanspub.org
原发性膜性肾病(Idoipathic membranous nephropathy, IMN) 是一种慢性肾小球疾病. IMN
是成人膜性肾病常见病理类型, 儿童较罕见, 近几年儿童IMN 发病率逐渐升高. 儿童IMN …