In cardiomyocytes, regular activity of the Na, K-ATPase (NKA) and its Na/K pump activity is
essential for maintaining ion gradients, excitability, propagation of action potentials, electro …

Millions of people visit high-altitude regions annually and more than 80 million live
permanently above 2,500 m. Acute high-altitude exposure can trigger high-altitude illnesses …

Introduction High-altitude pulmonary edema (HAPE) is a severe and potentially fatal
condition with limited treatment options. Although ceramide kinase (CERK)-derived …

The optimal function of the Na, K-ATPase (NKA) pump is essential for the heart. In ischemic
heart disease, NKA activity decreases due to the decreased expression of the pump …

Gastrointestinal dysfunction is a common symptom of acute mountain sickness (AMS). The
gut microbiota and γδ T cells play critical roles in intestinal disease. However, the …

Inflammation and hypoxia impair alveolar barrier tightness, inhibit Na-and fluid reabsorption,
and cause edema. We tested whether stimulated alveolar macrophages affect alveolar Na …

Background Hypoxia is associated with many respiratory diseases, partly due to the
accumulation of edema fluid and mucus on the surface of alveolar epithelial cell (AEC) …

The balance of gas exchange and lung ventilation is essential for the maintenance of body
homeostasis. There are many ion channels and transporters in respiratory epithelial cells …

Localized and chronic hypoxia of airway mucosa is a common feature of progressive
respiratory diseases, including cystic fibrosis (CF). However, the impact of prolonged …

Aerospace medicine required controlled terrestrial models to investigate influences of
altered atmosphere conditions, such as hypoxia, on human health and performance. These …