Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …

Finding faster and simpler ways to screen protein sequence space to enable the
identification of new biocatalysts for asymmetric synthesis remains both a challenge and a …

Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

Biocatalysis is an effective tool to access chiral molecules that are otherwise hard to
synthesize or purify. Time-efficient processes are needed to develop enzymes that …

The synthesis of structurally diverse amines is of fundamental significance in the
pharmaceutical industry due to the ubiquitous presence of amine motifs in biologically active …

Biocatalysis is a key technology in the pharmaceutical industry as it can provide efficient and
sustainable catalytic routes toward active pharmaceutical ingredients (APIs). The …

The synthesis of secondary and tertiary amines through the reductive amination of carbonyl
compounds is one of the most significant reactions in synthetic chemistry. Asymmetric …

Imine reductases (IREDs) are increasingly identified and characterized for the reduction of
imines and reductive amination of ketones. However, their practical application is still limited …