Normal cell-cycle progression is a crucial task for every multicellular organism, as it
determines body size and shape, tissue renewal and senescence, and is also crucial for …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

All cells possess long-term, steady-state voltage gradients across the plasma membrane.
These transmembrane potentials arise from the combined activity of numerous ion channels …

The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13
amplicon, one of the most frequently amplified chromosomal regions in human cancer, but …

Anion transporters based on small molecules have received attention as therapeutic agents
because of their potential to disrupt cellular ion homeostasis. However, a direct correlation …

In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …

Establishment of shape during embryonic development, and the maintenance of shape
against injury or tumorigenesis, requires constant coordination of cell behaviors toward the …

The potassium channel Kv1. 3 is highly expressed in the mitochondria of various cancerous
cells. Here we show that direct inhibition of Kv1. 3 using two mitochondria-targeted inhibitors …

Pattern formation, as occurs during embryogenesis or regeneration, is the crucial link
between genotype and the functions upon which selection operates. Even cancer and aging …