[HTML][HTML] Update on the epidemiology, genetics, and therapeutic options of hyperuricemia

L Li, Y Zhang, C Zeng - American journal of translational research, 2020 - ncbi.nlm.nih.gov
Hyperuricemia may occur when there is an excess of uric acid in the blood. Hyperuricemia
may result from increased production or decreased excretion of uric acid. Elevated uric acid …

[HTML][HTML] The role of the intestine in the development of hyperuricemia

H Yin, N Liu, J Chen - Frontiers in immunology, 2022 - frontiersin.org
Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in
the joints. Hyperuricemia is the fundamental factor of gout. The onset of hyperuricemia is …

[HTML][HTML] Blockade of autophagy prevents the progression of hyperuricemic nephropathy through inhibiting NLRP3 inflammasome-mediated pyroptosis

Y Hu, Y Shi, H Chen, M Tao, X Zhou, J Li, X Ma… - Frontiers in …, 2022 - frontiersin.org
Hyperuricemia has become a common metabolic disease, and is a risk factor for multiple
diseases, including chronic kidney disease. Our recent study indicated that following …

Fucoxanthin: A promising compound for human inflammation-related diseases

M Liu, W Li, Y Chen, X Wan, J Wang - Life sciences, 2020 - Elsevier
Fucoxanthin, a natural product of carotenoids, is a potential drug source obtained from
marine algae. The special chemical structure of fucoxanthin has equipped it with a variety of …

Therapeutic strategies for the treatment of chronic hyperuricemia: an evidence-based update

AFG Cicero, F Fogacci, M Kuwabara, C Borghi - Medicina, 2021 - mdpi.com
This article aims to critically review the evidence on the available therapeutic strategies for
the treatment of hyperuricemia. For this reason, several papers were reviewed. Xanthine …

Berberrubine attenuates potassium oxonate-and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway

G Lin, Q Yu, L Xu, Z Huang, L Mai, L Jiang, Z Su… - European Journal of …, 2021 - Elsevier
Abstract Phellodendri Chinensis Cortex (PC) is a traditional medicinal material used to treat
gout and hyperuricemia (HUA) in China. Berberine (BBR), the main component of PC …

[HTML][HTML] Clinical effects of xanthine oxidase inhibitors in hyperuricemic patients

AFG Cicero, F Fogacci, RI Cincione, G Tocci… - Medical principles and …, 2021 - karger.com
This review aims to critically present the available clinical evidence supporting the treatment
of chronic hyperuricemia with xanthine oxidase inhibitors. For this reason, the studies …

[HTML][HTML] Anti-hyperuricemic and nephroprotective effects of dihydroberberine in potassium oxonate-and hypoxanthine-induced hyperuricemic mice

L Xu, G Lin, Q Yu, Q Li, L Mai, J Cheng, J Xie… - Frontiers in …, 2021 - frontiersin.org
Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout.
Berberine (BBR), its characteristic ingredient, has also been shown to be effective in …

Engineered Escherichia coli Nissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment

R Zhao, Z Li, Y Sun, W Ge, M Wang, H Liu, L Xun… - Gut …, 2022 - Taylor & Francis
Hyperuricemia is the second most prevalent metabolic disease to human health after
diabetes. Only a few clinical drugs are available, and most of them have serious side effects …

Management of hyperuricemia in asymptomatic patients: a critical appraisal

A Brucato, F Cianci, C Carnovale - European Journal of Internal Medicine, 2020 - Elsevier
While there is consensus on starting urate-lowering therapy (ULT) in cases of symptomatic
hyperuricemia, the frequent condition of asymptomatic hyperuricemia (AH) remains a …