Thrombin: a pivotal player in hemostasis and beyond

JB Larsen, AM Hvas - Seminars in Thrombosis and Hemostasis, 2021 - thieme-connect.com
The serine protease thrombin, a naturally derived enzyme, plays a key role in hemostasis by
converting fibrinogen to fibrin and activating coagulation factor XIII whereby the fibrin clot is …

[HTML][HTML] Conventional versus miniaturized cardiopulmonary bypass: A systematic review and meta-analysis

T Cheng, R Barve, YWM Cheng, A Ravendren… - JTCVS open, 2021 - Elsevier
Objective A meta-analysis of randomized controlled trials was performed to compare the
effects of miniaturized extracorporeal circulation (MECC) and conventional extracorporeal …

2021 MiECTiS focused update on the 2016 position paper for the use of minimal invasive extracorporeal circulation in cardiac surgery

K Anastasiadis, P Antonitsis, J Murkin, C Serrick… - …, 2023 - journals.sagepub.com
The landmark 2016 Minimal Invasive Extracorporeal Technologies International Society
(MiECTiS) position paper promoted the creation of a common language between cardiac …

Minimal invasive extracorporeal circulation preserves coagulation integrity

H Argiriadou, P Antonitsis, A Gkiouliava… - …, 2022 - journals.sagepub.com
Introduction: Coagulopathy after cardiac surgery is a serious multifactorial complication that
results in postoperative bleeding requiring transfusion of red blood cells and procoagulant …

Fibrinolysis in cardiac arrest patients treated with hypothermia

AN Jeppesen, C Duez, H Kirkegaard… - Therapeutic …, 2023 - liebertpub.com
Hypothermia affects coagulation, but the effect of hypothermia on fibrinolysis is not clarified.
Imbalance in the fibrinolytic system may lead to increased risk of bleeding or thrombosis …

Impact of minimal invasive extracorporeal circulation on systemic inflammatory response–a randomized trial

DR Halle, LL Benhassen, KL Søberg… - Journal of …, 2024 - Springer
Background Extracorporeal circulation causes a systemic inflammatory response, that may
cause postoperative haemodynamic instability and end-organ dysfunction. This study aimed …

Individualized heparin monitoring and management reduces protamine requirements in cardiac surgery on minimal invasive extracorporeal circulation; A prospective …

A Gkiouliava, H Argiriadou, P Antonitsis, A Goulas… - …, 2023 - journals.sagepub.com
Introduction Individualized heparin and protamine management is increasingly used as a
strategy to reduce coagulation activation and bleeding complications. While it is associated …

Platelet preservation in cardiac surgery using minimally invasive extracorporeal circulation versus optimized cardiopulmonary bypass

B Beairsto, C Serrick, A Fernandez… - …, 2023 - journals.sagepub.com
Background Minimally invasive extracorporeal circulation (MiECC) is employed as a
strategy to attenuate the physiologic disturbance caused by cardiopulmonary bypass. The …

Modular minimally invasive extracorporeal circulation ensures perfusion safety and technical feasibility in cardiac surgery; a systematic review of the literature

K Anastasiadis, P Antonitsis, C Asteriou… - …, 2022 - journals.sagepub.com
Introduction: Despite extensive evidence that shows clinical of superiority of MiECC,
worldwide penetration remains low due to concerns regarding air handling and volume …

Pro: Is Minimally Invasive Extracorporeal Circulation Superior to Conventional Cardiopulmonary Bypass in Cardiac Surgery?

F Monaco, JDA Ursoleo - Journal of Cardiothoracic and Vascular …, 2024 - jcvaonline.com
DESPITE NUMEROUS TECHNOLOGIC advances and significant experience acquired in
surgical procedures using extracorporeal circulation, on-pump cardiac surgery is still not …