The serine protease thrombin, a naturally derived enzyme, plays a key role in hemostasis by
converting fibrinogen to fibrin and activating coagulation factor XIII whereby the fibrin clot is …

Objective A meta-analysis of randomized controlled trials was performed to compare the
effects of miniaturized extracorporeal circulation (MECC) and conventional extracorporeal …

The landmark 2016 Minimal Invasive Extracorporeal Technologies International Society
(MiECTiS) position paper promoted the creation of a common language between cardiac …

Introduction: Coagulopathy after cardiac surgery is a serious multifactorial complication that
results in postoperative bleeding requiring transfusion of red blood cells and procoagulant …

Hypothermia affects coagulation, but the effect of hypothermia on fibrinolysis is not clarified.
Imbalance in the fibrinolytic system may lead to increased risk of bleeding or thrombosis …

Introduction: Despite extensive evidence that shows clinical of superiority of MiECC,
worldwide penetration remains low due to concerns regarding air handling and volume …

Background Minimally invasive extracorporeal circulation (MiECC) is employed as a
strategy to attenuate the physiologic disturbance caused by cardiopulmonary bypass. The …

Introduction Individualized heparin and protamine management is increasingly used as a
strategy to reduce coagulation activation and bleeding complications. While it is associated …

DESPITE NUMEROUS TECHNOLOGIC advances and significant experience acquired in
surgical procedures using extracorporeal circulation, on-pump cardiac surgery is still not …

Background Cardiopulmonary bypass (CPB) causes coagulation disorders after surgery.
This study aimed to compare the coagulation parameters after congenital cardiac surgery …