Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

Essential hypertension can be defined as a rise in blood pressure of unknown cause that
increases risk for cerebral, cardiac, and renal events. In industrialised countries, the risk of …

Background: Optimal treatment to prevent or delay cognitive decline, mild cognitive
impairment (MCI), or dementia is uncertain. Purpose: To summarize current evidence on the …

Objectives: Prevention of cognitive decline and dementia with blood pressure lowering
treatments has shown inconsistent results. We compared the effects of different classes of …

Objective To investigate whether angiotensin receptor blockers protect against Alzheimer's
disease and dementia or reduce the progression of both diseases. Design Prospective …

The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has
implications for global health care. Both hypertension and hypotension affect brain perfusion …

Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

There is wide recognition of a complex association between midlife hypertension and
cardiovascular disease and later development of Alzheimer's disease (AD) and cognitive …

We investigated whether angiotensin II receptor blockers (ARBs) and angiotensin converting
enzyme inhibitors (ACE-Is) are more strongly associated with Alzheimer's disease (AD) …