Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias

NM Davies, PG Kehoe, Y Ben-Shlomo… - Journal of Alzheimer's …, 2011 - content.iospress.com
We investigated whether angiotensin II receptor blockers (ARBs) and angiotensin converting
enzyme inhibitors (ACE-Is) are more strongly associated with Alzheimer's disease (AD) …

Neurorestoration after traumatic brain injury through angiotensin II receptor blockage

S Villapol, MG Balarezo, K Affram, JM Saavedra… - Brain, 2015 - academic.oup.com
Abstract See Moon (doi: 10.1093/awv239) for a scientific commentary on this article.
Traumatic brain injury frequently leads to long-term cognitive problems and physical …

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model

B Ongali, N Nicolakakis, XK Tong, T Aboulkassim… - Neurobiology of …, 2014 - Elsevier
Angiotensin II (AngII) receptor blockers that bind selectively AngII type 1 (AT1) receptors may
protect from Alzheimer's disease (AD). We studied the ability of the AT1 receptor antagonist …

The renin angiotensin system and the brain: new developments

E Farag, DI Sessler, Z Ebrahim, A Kurz… - Journal of Clinical …, 2017 - Elsevier
The traditional renin-angiotensin system (RAS) is indispensable system in adjusting sodium
homeostasis, body fluid volume, and controlling arterial blood pressure. The key elements …

The association of multiple anti-hypertensive medication classes with Alzheimer's disease incidence across sex, race, and ethnicity

D Barthold, G Joyce, W Wharton, P Kehoe… - PloS one, 2018 - journals.plos.org
Background Antihypertensive treatments have been shown to reduce the risk of Alzheimer's
disease (AD). The renin-angiotensin system (RAS) has been implicated in AD, and thus …

Factors associated with decreased cerebral blood flow in congestive heart failure secondary to idiopathic dilated cardiomyopathy

BR Choi, JS Kim, YJ Yang, KM Park, CW Lee… - The American journal of …, 2006 - Elsevier
Cerebral blood flow (CBF) is decreased and cognitive dysfunction develops in the advanced
stages of heart failure. However, few data are available regarding the factors associated with …

Use of angiotensin-converting enzyme inhibitors and variations in cognitive performance among patients with heart failure

G Zuccala, G Onder, E Marzetti… - European heart …, 2005 - academic.oup.com
Aims Cognitive dysfunction is a prevalent condition among patients with heart failure, and is
independently associated with disability and mortality. Angiotensin-converting enzyme …

Effects of valsartan compared with enalapril on blood pressure and cognitive function in elderly patients with essential hypertension

R Fogari, A Mugellini, A Zoppi, G Marasi… - European Journal of …, 2004 - Springer
Objective This prospective, randomised, open-label, blinded-endpoint study was to compare
the effects of the angiotensin II (Ang II) AT1 receptor antagonist valsartan with those of the …

Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors

W Froestl, A Muhs, A Pfeifer - Journal of Alzheimer's disease, 2012 - content.iospress.com
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

Angiotensin II receptor blockers attenuate lipopolysaccharide-induced memory impairment by modulation of NF-κB-mediated BDNF/CREB expression and apoptosis …

R Goel, SA Bhat, K Hanif, C Nath, R Shukla - Molecular Neurobiology, 2018 - Springer
Clinical studies demonstrated a positive correlation between hypertension and cognitive
decline. Beneficial effects of angiotensin II receptor blockers on cognitive functions have …