Background: Hypertension is associated with impaired cognitive function but the effect of
antihypertensive treatment on cognitive function is unclear. Methods: We investigated the …

Our review of cohort studies and clinical trials evaluating antihypertensive drugs in the
prevention of cognition decline and all dementia in patients with hypertension indicates that …

Protein and lipid oxidation—mainly by mitochondrial reactive oxygen species (mtROS)—
was proposed as a crucial determinant of health and lifespan. Angiotensin II (Ang II) …

Management of hypertension in the elderly should take into account, in particular, the
possible negative impact of antihypertensive drugs on the patient's quality of life, the …

Background Stress and various stress hormones, including catecholamines and
glucocorticoids, have recently been implicated in the pathogenesis of Alzheimer's disease …

The renin-angiotensin system (RAS) is one of the best-studied enzyme-neuropeptide
systems in the brain and can serve as a model for the action of peptides on neuronal …

Cognitive dysfunction syndrome (CDS) is an established condition in cats that shares many
similarities with human Alzheimer's disease (AD), where cognitive decline ultimately results …

Background: Centrally acting angiotensin converting enzyme inhibitors (CACE-Is) are
associated with reduced rates of cognitive decline in patients with dementia. CACE-Is may …

All the components of the classic renin–angiotensin system (RAS) have been identified in
the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor …

Background Prior work suggests that some but not all antihypertensive treatments may
benefit cognition and risk for Alzheimer's disease, independent of stroke. Angiotensin II …