Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Highlights•Hsp90 is a molecular chaperone that modulates the function of many client
proteins.•Morphogenesis is an important Candida albicans virulence trait.•Hsp90 regulates …

Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …

Fluconazole has characteristics that make it widely used in the clinical treatment of C.
albicans infections. However, fluconazole has only a fungistatic activity in C. albicans …

In the past few decades, the development of heat shock protein 90 (Hsp90) inhibitors for
cancer treatment has not stopped. About twenty compounds have been evaluated in the …

With the widespread use of immunosuppressive agents and the increase in patients with
severe infections, the incidence of fungal infections worldwide has increased year by year …

Human fungal pathogens are the causative agents of devastating diseases across the
globe, and the increasing prevalence of drug resistance threatens to undermine the already …

The growing occurrence of invasive fungal infections and the mounting rates of drug
resistance constitute a significant menace to human health. Antifungal drug combinations …

Clinical treatment of candidiasis has suffered from increasingly severe drug resistance and
limited efficacy. Thus, novel strategies to deal with drug resistance are highly desired to …