HDAC6 and Hsp90, existing as a cytosolic complex play an important role in maintaining the
protein homeostasis. The interplay of HDAC6 and Hsp90 has attracted wide attention due to …

Highlights•Fungi have a serious impact on human health, causing millions of deaths
worldwide.•Scientific advances have enabled the discovery of novel antifungals.•This review …

Candida albicans is the most common fungal pathogen. Recently, drug resistance of C.
albicans is increasingly severe. Hsp90 is a promising antifungal target to overcome this …

Biomimetics, which are similar to natural compounds that play an important role in the
metabolism, manifestation of functional activity and reproduction of various fungi, have a …

Understanding the how behind the polyphyletic trait of fungal thermotolerance has important
implications to both medical and industrial pursuits. In this review, our goal is to synthesize …

Four series of novel pyrazole derivatives (compounds 17a–m, 18a–m, 19a–g, and 20a–g)
were synthesized, and their antibacterial and antifungal activities were evaluated. Most of …

Heat shock protein 90 (HSP90) is a critical target for anticancer and anti-fungal-infection
therapies due to its central role as a molecular chaperone involved in protein folding and …

Protein homeostasis is critical for proliferation and viability of all organisms. For Candida
albicans, protein homeostasis also modulates the transition between yeast and filamentous …

The heat shock proteins (HSPs) function as chaperones to facilitate proper folding and
modification of proteins and are of particular importance when organisms are subjected to …

Fungi inhabit extraordinarily diverse ecological niches, including the human body. Invasive
fungal infections have a devastating impact on human health worldwide, killing∼ 1.5 million …