SLE is characterised by an activation of the interferon (IFN) system, which leads to an
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …

Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers
and Activators of Transcription) pathway, play a central role in the pathogenesis of …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …

Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

Background We studied 2 unrelated patients with immune thrombocytopenia and
autoimmune hemolytic anemia in the setting of acute infections. One patient developed …

The interferons (IFNs) were originally described over 50 years ago, identified by their ability
to confer viral resistance to cells. We now know that they are much more than just anti‐viral …

Objectives The relationship of immune dysregulation and autoantibody production that may
contribute to systemic lupus erythematosus (SLE) pathogenesis is unknown. This study …

SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the
Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 …

The etiopathogenesis of systemic lupus erythematosus (SLE), a clinically heterogeneous
multisystemic syndrome that derives its name from the initial characterization of facial …