More than 15 years have passed since the official completion of the Human Genome
Project. Predominantly due to this project, over one hundred genes have now been linked to …

Adeno-associated virus (AAV)-mediated gene transfer has shown promise in rescuing
mouse models of genetic hearing loss, but how viral capsid and promoter selection affects …

The number of patients with hearing loss is on the rise due to congenital abnormalities,
degenerative changes in old age, and acquired injuries such as virus or ototoxic drug …

Auditory brainstem responses (ABRs) are evoked potentials that are measured from the
scalp and reflect the activity of the auditory neurons in the auditory pathway in response to …

Therapeutic strategies to restore hearing and balance in mouse models of inner ear disease
aim to rescue sensory function by gene replacement, augmentation, knock down or knock …

Novel hearing therapeutics are rapidly progressing along the innovation pathway and into
the clinical trial domain. Because these trials are new to the hearing community, they come …

Most of episodic or progressive syndromes show familial clustering. A detailed phenotyping
with a complete familial history of vestibular symptoms is required to conduct a genetic …

Inner ear gene therapy offers great promise as a potential treatment for hearing loss and
dizziness. One of the critical determinants of the success of inner ear gene therapy is to find …

Over 450 million people worldwide suffer from hearing loss, leading to an estimated
economic burden of∼ $750 billion. The past decade has seen significant advances in the …

Disabling hearing loss is expected to affect over 900 million people worldwide by 2050. The
World Health Organization estimates that the annual economic impact of hearing loss …