Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …

The bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be
improved via the formulation of an amorphous solid dispersion (ASD), where the API is …

Miscibility is an important indicator of physical stability against crystallization of amorphous
solid dispersions (ASDs). Currently available methods for miscibility determination have …

Several literature publications have described the potential application of active
pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate …

Abstract Topical patches containing 5-fluorouracil (5-FU) are a feasible alternative to
overcome the shortcomings of commercial cream for the treatment of non-melanoma skin …

This paper aimed to improve in vitro dissolution/solubility as well as inhibit intestinal
metabolism and thus enhance oral bioavailability for a BDDCS class II drug by constructing …

An innovative strategy to address recent challenges in the oral administration of poorly
soluble drugs is the formulation of amorphous solid dispersions (ASDs), where the drug is …

Overcoming the poor water solubility of small-molecule drugs is a major challenge in the
development of clinical pharmaceuticals. Amorphization of crystalline drugs is a highly …

Aim of this study was to improve nevirapine solubility using solid dispersion technique and
applying molecular modeling to assess drug-polymer interactions. Solid dispersions were …