TGF-β signaling pathway: Therapeutic targeting and potential for anti-cancer immunity
Transforming growth factor-β (TGFβ) is a pleiotropic secretory cytokine exhibiting both
cancer-inhibitory and promoting properties. It transmits its signals via Suppressor of Mother …
cancer-inhibitory and promoting properties. It transmits its signals via Suppressor of Mother …
The love-hate relationship between TGF-β signaling and the immune system during development and tumorigenesis
B Chen, C Mu, Z Zhang, X He, X Liu - Frontiers in immunology, 2022 - frontiersin.org
Since TGF-β was recognized as an essential secreted cytokine in embryogenesis and adult
tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian …
tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian …
The involvement of epithelial-to-mesenchymal transition in doxorubicin resistance: Possible molecular targets
Considering the fact that cancer cells can switch among various molecular pathways and
mechanisms to ensure their progression, chemotherapy is no longer effective enough in …
mechanisms to ensure their progression, chemotherapy is no longer effective enough in …
[HTML][HTML] Understanding the complex milieu of epithelial-mesenchymal transition in cancer metastasis: new insight into the roles of transcription factors
Epithelial-mesenchymal transitions (EMT) are physiological programs during which
polarized, immobile epithelial cells lose connection with their neighbours and are converted …
polarized, immobile epithelial cells lose connection with their neighbours and are converted …
A computational systems biology approach identifies SLUG as a mediator of partial Epithelial-Mesenchymal Transition (EMT)
Epithelial-mesenchymal plasticity comprises reversible transitions among epithelial, hybrid
epithelial/mesenchymal (E/M) and mesenchymal phenotypes, and underlies various aspects …
epithelial/mesenchymal (E/M) and mesenchymal phenotypes, and underlies various aspects …
[HTML][HTML] Epithelial-mesenchymal transition-inducing factors involved in the progression of lung cancers
Although there have been advances in cancer therapy and surgical improvement, lung
cancer has the lowest survival rate (19%) at all stages. This is because most patients are …
cancer has the lowest survival rate (19%) at all stages. This is because most patients are …
Genome-editing-mediated restructuring of tumor immune microenvironment for prevention of metastasis
Modulating the tumor immune microenvironment to activate immune cells has been
investigated to convert cold to hot tumors. Here, we report that metal–lipid hybrid …
investigated to convert cold to hot tumors. Here, we report that metal–lipid hybrid …
AVA-NP-695 selectively inhibits ENPP1 to activate STING pathway and abrogate tumor metastasis in 4T1 breast cancer syngeneic mouse model
A Goswami, B Deb, S Goyal, A Gosavi, M Mali… - Molecules, 2022 - mdpi.com
Cyclic GMP-AMP synthase (cGAS) is an endogenous DNA sensor that synthesizes cyclic
guanosine monophosphate–adenosine monophosphate (2′ 3′-cGAMP) from ATP and …
guanosine monophosphate–adenosine monophosphate (2′ 3′-cGAMP) from ATP and …
Active demethylation upregulates CD147 expression promoting non-small cell lung cancer invasion and metastasis
CG Liao, XH Liang, Y Ke, L Yao, M Liu, ZK Liu, L He… - Oncogene, 2022 - nature.com
Non-small cell lung cancer (NSCLC) is a fatal disease, and its metastatic process is poorly
understood. Although aberrant methylation is involved in tumor progression, the …
understood. Although aberrant methylation is involved in tumor progression, the …
Revisiting epithelial carcinogenesis
LF Méndez-López - International Journal of Molecular Sciences, 2022 - mdpi.com
The origin of cancer remains one of the most important enigmas in modern biology. This
paper presents a hypothesis for the origin of carcinomas in which cellular aging and …
paper presents a hypothesis for the origin of carcinomas in which cellular aging and …