Organoids: The current status and biomedical applications
S Yang, H Hu, H Kung, R Zou, Y Dai, Y Hu… - MedComm, 2023 - Wiley Online Library
Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …
Organoid: Bridging the gap between basic research and clinical practice
G Weng, J Tao, Y Liu, J Qiu, D Su, R Wang, W Luo… - Cancer Letters, 2023 - Elsevier
Nowadays, the diagnosis and treatment system of malignant tumors has increasingly tended
to be more precise and personalized. And the existing tumor models are still unable to fully …
to be more precise and personalized. And the existing tumor models are still unable to fully …
Integration of pan-omics technologies and three-dimensional in vitro tumor models: an approach toward drug discovery and precision medicine
Despite advancements in treatment protocols, cancer is one of the leading cause of deaths
worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets …
worldwide. Therefore, there is a need to identify newer and personalized therapeutic targets …
BUB1 Promotes Gemcitabine Resistance in Pancreatic Cancer Cells by Inhibiting Ferroptosis
W Wang, X Zhou, L Kong, Z Pan, G Chen - Cancers, 2024 - mdpi.com
Simple Summary Further investigation into the molecular mechanisms of chemotherapy
resistance in pancreatic cancer is crucial for improving the prognosis of pancreatic cancer …
resistance in pancreatic cancer is crucial for improving the prognosis of pancreatic cancer …
Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer
T Seidlitz, T Schmäche, JH Lee, N Qin… - EMBO Molecular …, 2022 - embopress.org
Gastric cancer ranks the fifth most common and third leading cause of cancer‐related deaths
worldwide. Alterations in the RTK/MAPK, WNT, cell adhesion, TP53, TGFβ, NOTCH, and …
worldwide. Alterations in the RTK/MAPK, WNT, cell adhesion, TP53, TGFβ, NOTCH, and …
[HTML][HTML] Overcoming therapy resistance in pancreatic cancer: New insights and future directions
M Espona-Fiedler, C Patthey, S Lindblad, I Sarró… - Biochemical …, 2024 - Elsevier
Pancreatic adenocarcinoma (PDAC) is predicted to become the second leading cause of
cancer deaths by 2030 and this is mostly due to therapy failure. Limited treatment options …
cancer deaths by 2030 and this is mostly due to therapy failure. Limited treatment options …
Combined systemic drug treatment with proton therapy: Investigations on patient-derived organoids
M Naumann, T Czempiel, AJ Lößner, K Pape… - Cancers, 2022 - mdpi.com
Simple Summary Radiotherapy is part of the standard of care for many solid tumors. In
pancreatic ductal adenocarcinoma (PDAC), good responses to radiotherapy can only be …
pancreatic ductal adenocarcinoma (PDAC), good responses to radiotherapy can only be …
[HTML][HTML] Emerging roles of 3D-culture systems in tackling tumor drug resistance
A Nikdouz, F Orso - Cancer Drug Resistance, 2023 - ncbi.nlm.nih.gov
Drug resistance that affects patients universally is a major challenge in cancer therapy. The
development of drug resistance in cancer cells is a multifactor event, and its process …
development of drug resistance in cancer cells is a multifactor event, and its process …
The application of pancreatic cancer organoids for novel drug discovery
Introduction Pancreatic ductal adenocarcinoma presents with a dismal prognosis.
Personalized therapy is urgently warranted to overcome the treatment limitations of the 'one …
Personalized therapy is urgently warranted to overcome the treatment limitations of the 'one …
The combined prognostic model of copper-dependent to predict the prognosis of pancreatic cancer
X Guan, N Lu, J Zhang - Frontiers in Genetics, 2022 - frontiersin.org
Purpose: To assess the prognostic value of copper-dependent genes, copper-dependent-
related genes (CDRG), and CDRG-associated immune-infiltrating cells (CIC) for pancreatic …
related genes (CDRG), and CDRG-associated immune-infiltrating cells (CIC) for pancreatic …