Oxidative stress is a complex biological process characterized by the excessive production
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …

Although heart failure due to a wide variety of pathological stimuli including myocardial
infarction, pressure overload and volume overload is associated with cardiac hypertrophy …

The prevalence of diabetes is growing at an alarming rate with increased disability,
morbidity, and often premature mortality because of the various complications of this …

Diabetes mellitus (DM) and cardiovascular complications are two unmet medical
emergencies that can occur together. The rising incidence of heart failure in diabetic …

By virtue of their regulatory role in various metabolic and biosynthetic pathways for energy
status and cellular integrity, both hydro-soluble and lipo-soluble vitamins are considered to …

Herein we trace links between biochemical pathways, pathogenesis, and metabolic
diseases to set the stage for new therapeutic advances. Cellular and acellular …

It is now well known that oxidative stress promotes lipid peroxidation, protein oxidation,
activation of proteases, fragmentation of DNA and alteration in gene expression for …

Ischemia-reperfusion (I/R) injury is well-known to be associated with impaired cardiac
function, massive arrhythmias, marked alterations in cardiac metabolism and irreversible …

Adipokines play a significant role in cardiometabolic diseases. Asprosin, a newly discovered
adipokine, was first identified as a glucose-raising protein hormone. Asprosin also …

Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the
human brain both under basal conditions and in response to somatosensory stimulation. An …