Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to
coordinate cell growth, metabolism and autophagy. Extensive research has mapped the …

LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7
family. A role for LIN28B in cancer has been proposed but has not been established in vivo …

MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …

One of the most ancient and highly conserved microRNAs (miRNAs), the let-7 family, has
gained notoriety owing to its regulation of stem cell differentiation and essential role in …

The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …

An emerging view emphasizes that metabolism is highly regulated in both time and space.
In addition, it is increasingly being recognized that metabolic pathways are tightly connected …

LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via
regulation of the microRNA let-7. However, recent studies have uncovered new roles for …

LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and
oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) …