Abstract l-tryptophan, an essential amino acid, regulates protein homeostasis and plays a
role in neurotransmitter-mediated physiological events. It also influences age-associated …

Alzheimer's disease (AD) is the leading cause of dementia in older individuals and is an
escalating challenge to global public health. Pharmacy therapy of AD is one of the well …

The aggregation of α-synuclein (α-syn) promotes neuroinflammation and neuronal
apoptosis, which eventually contribute to the pathogenesis of Parkinson's disease (PD). Our …

The prevalence of neurodegenerative diseases (NDs) is increasing due to the aging
population and improved longevity. They are characterized by a range of pathological …

Pancreatic ductal adenocarcinoma (PDAC) is the most common exocrine tumor of the
pancreas characterized by late diagnosis, adverse overall 5-year survival, a higher …

Hypoxia is characterized by low oxygen levels in the body or environment, resulting in
various physiological and pathological changes. The brain, which has the highest oxygen …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and the
most prevalent form of dementia. The main hallmarks for the diagnosis of AD are …

The discovery of neuroglobin (Ngb), a brain-or neuron-specific member of the hemoglobin
family, has revolutionized our understanding of brain oxygen metabolism. Currently, how …

Introduction Alzheimer's disease (AD) causes a decline in cognitive function that poses a
significant hazard to human health. However, the exact pathogenesis of AD and effective …

Due to the increase of life expectancy, the world aging population has been increasing
significantly and is expected to triple by 2050. Aging is a physiological change characterized …