Hypertension is a major risk factor for cardiovascular mortality and morbidity through its
effects on target organs like the brain, heart, and kidney. Structural alterations in the …

Stroke is the second most common cause of death worldwide and of adult disability, but in
the near future the global burden of cerebrovascular diseases will rise due to ageing and …

Essential hypertension is a multifactorial disorder and is the main risk factor for renal and
cardiovascular complications. The research on the genetics of hypertension has been …

Diabetes and hypertension frequently coexist, and their combination provides additive
increases in the risk of life-threatening cardiovascular events. Recent guidelines agree on …

The prevalence of the metabolic syndrome is increasing owing to lifestyle changes leading
to obesity. This syndrome is a complex association of several interrelated abnormalities that …

Methods: Two databases we had previously identified [72 placebo-controlled BP-lowering
randomized clinical trials (RCTs) in 260 210 individuals and 50 RCTs head-to-head …

Patients with non–dialysis-dependent chronic kidney disease (NDD-CKD) are 10 times
more likely to die of cardiovascular (CV) diseases than the general population, and dialysis …

Calcium antagonists were introduced for the treatment of hypertension in the 1980s. Their
use was subsequently expanded to additional disorders, such as angina pectoris …

Objective To test for the first time the hypothesis that treatment of hypertensive patients at
high cardiovascular risk with the angiotensin-receptor blocker (ARB) valsartan prevents new …

Background Hypertension is an important risk factor for adverse cardiovascular events
including stroke, myocardial infarction, heart failure and renal failure. The main goal of …