Over the past 15 years, there has been great interest in the potential to repurpose the
diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts …

The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus,
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …

The quest to repurpose metformin, an antidiabetes drug, as an agent for cancer prevention
and treatment, which began in 2005 with an observational study that reported a reduction in …

As a main subtype of lung cancer, the current situation of non-small cell lung cancer
(NSCLC) remains severe worldwide with a 19% survival rate at 5 years. As the conventional …

Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer metastasis,
accompanied with vast epigenetic changes. AMP-activated protein kinase (AMPK), a cellular …

Simple Summary This literature analysis is focused on the pleiotropic action associated with
metformin treatment. Precisely, metformin treatment exerts many health effects, mainly by …

Background To investigate whether metformin monotherapy or adjunctive therapy improves
the prognosis in patients with any type of cancer compared to non-metformin users (age≥ …

Metformin's effect on tumor treatment was complex, because it significantly reduced cancer
cell proliferation in vitro, but made no difference in prognosis in several clinical cohorts. Our …

Tinnitus, a phantom perception of sound in the absence of any external sound source, is a
prevalent health condition often accompanied by psychiatric comorbidities. Recent genome …

Metformin and IACS‐010759 are two distinct antimetabolic agents. Metformin, an
established antidiabetic drug, mildly inhibits mitochondrial complex I, while IACS‐010759 is …