Neuropeptide Y (NPY) is one the most potent orexigenic peptides found in the brain. It
stimulates food intake with a preferential effect on carbohydrate intake. It decreases latency …

Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades …

The bHLH-PAS transcription factor SIM1 is required for the development of the
paraventricular nucleus (PVN) of the hypothalamus. Mice homozygous for a null allele of …

Some, but not all, fats are obesogenic. The aim of the present studies was to investigate the
effects of changing type and amount of dietary fats on energy balance, fat deposition, leptin …

This review focuses on the expression, content, and release of neuropeptides and on their
role in the development of obesity in animal models with single-gene mutations. The …

Scientific and commercial pharmacological interest in the role of galanin and galanin
receptors in the regulation of food intake, energy balance, and obesity has waned recently …

Galanin inhibits food consumption in satiated rats. Discovered relatively recently, galanin is
a 29-amino-acid neuropeptide, not homologous with any other known peptide. Three G …

Objective: To characterize and compare three obesity-prone inbred strains, AKR/J, DBA/2J
and C57BL/6J, to three control strains, C3H/HeJ, BALB/cByJ and C57L/J, selected based on …

The last 25 years have seen a great increase in the incidence of obesity, both in the Western
world and in developing third world countries. Despite the seeming inexorable progression …

Previous studies have suggested that the peptide galanin (GAL) in the hypothalamus is
related to the preference of an animal for dietary fat. The present report investigates this …