[HTML][HTML] Role of neuroinflammation in amyotrophic lateral sclerosis: cellular mechanisms and therapeutic implications
J Liu, F Wang - Frontiers in immunology, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …
[HTML][HTML] Comprehensive research on past and future therapeutic strategies devoted to treatment of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
Protein aggregation and neurodegenerative diseases: From theory to therapy
The study of protein misfolding and aggregation saw resurgence in the last decade.
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Role of melatonin in the inflammatory process and its therapeutic potential
Melatonin is an indolamine synthesized and secreted by the pineal gland along with other
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …
extrapineal sources including immune system cells, the brain, skin and the gastrointestinal …
[HTML][HTML] Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits
Abstract α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of
mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective …
mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective …
[HTML][HTML] Increased interleukin-6 levels in the astrocyte-derived exosomes of sporadic amyotrophic lateral sclerosis patients
Y Chen, K Xia, L Chen, D Fan - Frontiers in Neuroscience, 2019 - frontiersin.org
Neuroinflammation plays an important role in amyotrophic lateral sclerosis (ALS)
pathogenesis. However, it is difficult to evaluate inflammation of the central nervous system …
pathogenesis. However, it is difficult to evaluate inflammation of the central nervous system …
A review on cyclin-dependent kinase 5: An emerging drug target for neurodegenerative diseases
Abstract Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly
found in the brain and plays a significant role in developing the central nervous system …
found in the brain and plays a significant role in developing the central nervous system …
The role of inflammation in neurological disorders
Traditionally neurological diseases have been classified, on the basis of their pathogenesis,
into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main …
into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main …
Intersection of network medicine and machine learning towards investigating the key biomarkers and pathways underlying amyotrophic lateral sclerosis: a systematic …
Background Network medicine is an emerging area of research that focuses on delving into
the molecular complexity of the disease, leading to the discovery of network biomarkers and …
the molecular complexity of the disease, leading to the discovery of network biomarkers and …
[HTML][HTML] Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1
Conserved telomere maintenance component 1 (CTC1) is an important component of the
CST (CTC1-STN1-TEN1) complex, involved in maintaining the stability of telomeric DNA …
CST (CTC1-STN1-TEN1) complex, involved in maintaining the stability of telomeric DNA …