Advanced therapeutics, vaccinations, and precision medicine in the treatment and management of chronic hepatitis b viral infections; where are we and where are we …
GS Duraisamy, D Bhosale, I Lipenská, I Huvarova… - Viruses, 2020 - mdpi.com
The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet
clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide …
clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide …
Genomics and infectious disease: a call to identify the ethical, legal and social implications for public health and clinical practice
Advances in genomics are contributing to the development of more effective, personalized
approaches to the prevention and treatment of infectious diseases. Genetic sequencing …
approaches to the prevention and treatment of infectious diseases. Genetic sequencing …
[HTML][HTML] Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease
JE Horowitz, JA Kosmicki, A Damask, D Sharma… - MedRxiv, 2020 - medrxiv.org
The need to identify and effectively treat COVID-19 cases at highest risk for severe disease
is critical. We identified seven common genetic variants (three novel) that modulate COVID …
is critical. We identified seven common genetic variants (three novel) that modulate COVID …
GWAS identifying HLA‐DPB1 gene variants associated with responsiveness to hepatitis B virus vaccination in Koreans: Independent association of HLA‐DPB1* 04 …
S Chung, EY Roh, B Park, Y Lee, S Shin… - Journal of Viral …, 2019 - Wiley Online Library
Recently, HLA class II loci, including HLA‐DPB1, have been reported to be associated with
interindividual variance in the hepatitis B (HB) vaccine response. In this study, we …
interindividual variance in the hepatitis B (HB) vaccine response. In this study, we …
Beyond metabolism: role of the immune system in hepatic toxicity
KL Hastings, MD Green, B Gao… - … journal of toxicology, 2020 - journals.sagepub.com
The liver is primarily thought of as a metabolic organ; however, the liver is also an important
mediator of immunological functions. Key perspectives on this emerging topic were …
mediator of immunological functions. Key perspectives on this emerging topic were …
Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development
L Yu, Y Cheng, M Cheng, Y Yao, Q Zhang, X Zhao… - Scientific reports, 2015 - nature.com
Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB),
liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, genome-wide …
liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, genome-wide …
A missense variant in complement factor B (CFB) is a potential predictor of 24‐week off‐treatment response to PegIFNα therapy in Chinese HBeAg‐positive chronic …
H Chen, J Sun, B Zhou, J Peng, Q Xie… - Alimentary …, 2020 - Wiley Online Library
Background To date, 14 single‐nucleotide polymorphisms (SNPs) have been identified as
susceptibility loci for chronic hepatitis B (CHB). Aim To investigate if these SNPs are …
susceptibility loci for chronic hepatitis B (CHB). Aim To investigate if these SNPs are …
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci of STAT4 and HLA-DQ in a Korean population
LH Kim, HS Cheong, S Namgoong, JO Kim… - Infection, Genetics and …, 2015 - Elsevier
A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related
hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in …
hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in …
Genetic insights on host and hepatitis B virus in liver diseases
Hepatitis B virus (HBV) infection is a major global health problem and many studies have
underlined the importance of inter individual variability and somatic mutations during the …
underlined the importance of inter individual variability and somatic mutations during the …
Genome-wide association study for chronic hepatitis B infection in the Thai Population
To identify novel host genetic variants that predispose to hepatitis B virus (HBV) persistence,
we performed the first genome-wide association study in the Thai population involving 318 …
we performed the first genome-wide association study in the Thai population involving 318 …