Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus
Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …
The link between circulating follicular helper T cells and autoimmunity
LSK Walker - Nature Reviews Immunology, 2022 - nature.com
Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …
centres that allow affinity maturation of antibody responses. Although usually located in …
The role of the immune system in the development of endometriosis
Endometriosis is a chronic disease that affects about 10% of women of reproductive age. It
can contribute to pelvic pain, infertility or other conditions such as asthma, cardiovascular …
can contribute to pelvic pain, infertility or other conditions such as asthma, cardiovascular …
The immunology of host defence peptides: beyond antimicrobial activity
Host defence peptides (HDPs) are short, cationic amphipathic peptides with diverse
sequences that are produced by various cells and tissues in all complex life forms. HDPs …
sequences that are produced by various cells and tissues in all complex life forms. HDPs …
Interleukin-1β induces mtDNA release to activate innate immune signaling via cGAS-STING
LD Aarreberg, K Esser-Nobis, C Driscoll, A Shuvarikov… - Molecular cell, 2019 - cell.com
Summary Interleukin-1 beta (IL-1β) is a pleiotropic mediator of inflammation and is produced
in response to a wide range of stimuli. During infection, IL-1β production occurs in parallel …
in response to a wide range of stimuli. During infection, IL-1β production occurs in parallel …
Functional hallmarks of healthy macrophage responses: their regulatory basis and disease relevance
KM Sheu, A Hoffmann - Annual review of immunology, 2022 - annualreviews.org
Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …
Regulation of type I interferon responses
LB Ivashkiv, LT Donlin - Nature Reviews Immunology, 2014 - nature.com
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …
development of innate and adaptive immune responses. Canonical type I IFN signalling …
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
High-throughput single-cell transcriptomics offers an unbiased approach for understanding
the extent, basis and function of gene expression variation between seemingly identical …
the extent, basis and function of gene expression variation between seemingly identical …
Immune signaling by RIG-I-like receptors
YM Loo, M Gale - Immunity, 2011 - cell.com
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen
sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect …
sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect …
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized by
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …