Better living through understanding the insula: Why subregions can make all the difference

SW Centanni, AC Janes, DL Haggerty, B Atwood… - …, 2021 - Elsevier
Insula function is considered critical for many motivated behaviors, with proposed functions
ranging from attention, behavioral control, emotional regulation, goal-directed and aversion …

Still a “hidden island”? The rodent insular cortex in drug seeking, reward, and risk

MS McGregor, RT LaLumiere - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Abstract MCGREGOR, MS, and RT LaLumiere. Still a “hidden island”? The rodent insular
cortex in drug seeking, reward, and risk. NEUROSCI BIOBEHAV REV 21 (1) XXX-XXX …

Compulsive drug-taking is associated with habenula–frontal cortex connectivity

Y Duan, PJ Tsai, BJ Salmeron, Y Hu… - Proceedings of the …, 2022 - National Acad Sciences
As a critical node connecting the forebrain with the midbrain, the lateral habenula (LHb)
processes negative feedback in response to aversive events and plays an essential role in …

[HTML][HTML] Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking

PA Starski, TDO Sergio, FW Hopf - Addiction Neuroscience, 2023 - Elsevier
Alcohol use disorder extracts substantial personal, social and clinical costs, and continued
intake despite negative consequences (compulsion-like consumption) can contribute …

Neural Activity in the Anterior Insula at Drinking Onset and Licking Relates to Compulsion-Like Alcohol Consumption

P Starski, MD Morningstar, SN Katner… - Journal of …, 2024 - Soc Neuroscience
Much remains unknown about the etiology of compulsion-like alcohol drinking, where
consumption persists despite adverse consequences. The role of the anterior insula (AIC) in …

Sex-and estrous-related response patterns for alcohol depend critically on the level of compulsion-like challenge

TDO Sergio, D Darevsky, J Kellner… - Progress in Neuro …, 2024 - Elsevier
Alcohol use disorder is a substantial social and economic burden. During the last years, the
number of women with drinking problems has been increasing, and one main concern is …

Insula lesions reduce stimulus-driven control of behavior during odor-guided decision-making and autoshaping

HJ Pribut, XA Sciarillo, MR Roesch - Brain research, 2022 - Elsevier
The insula has become a significant brain region in the study of both normal and impaired
behavior and decision-making and has emerged as an important contributor to drug …

Lickometry to Circuitry: How Compulsion-Like Alcohol Drinking Microstructure Helped Discover Functional Differences in Salience Network Regions

TDO Sergio, PA Starski, FW Hopf - Translational Research Methods for …, 2023 - Springer
Problem alcohol drinking remains an enormous personal, social, and clinical challenge, and
compulsion-like drinking (intake despite known negative consequences) can strongly …

Evidence for different greater-persistence strategies under lower and higher challenge for alcohol in female rats

T De Oliveira Sergio, D Darevsky, V de Paula Soares… - Biorxiv, 2022 - biorxiv.org
Problem alcohol drinking is a substantial social and economic burden. Studies show that the
misuse of alcohol is increasing in women, and that women can face higher consequences …

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

P Starski, M Morningstar, S Katner, R Frasier… - Biorxiv, 2022 - biorxiv.org
Compulsive-like alcohol drinking (CLAD), where intake persists despite adverse
consequences, is often a core facet of alcohol use disorder. Recent work sheds light on …