CK2 in cancer: cellular and biochemical mechanisms and potential therapeutic target

MMJ Chua, CE Ortega, A Sheikh, M Lee… - Pharmaceuticals, 2017 - mdpi.com
CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise

JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023 - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Casein kinases as potential therapeutic targets

G Cozza, LA Pinna - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: The conventional term 'casein kinase'(CK) denotes three classes of kinases–
CK1, CK2 and Golgi-CK (G-CK)/Fam20C (family with sequence similarity 20, member C) …

[HTML][HTML] Protein kinase CK2, a potential therapeutic target in carcinoma management

H Lian, M Su, Y Zhu, Y Zhou… - Asian Pacific journal of …, 2019 - ncbi.nlm.nih.gov
The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved
serine/threonine kinase overexpressed in various human carcinomas and its high …

Examination of CK2α and NF-κB p65 expression in human benign prostatic hyperplasia and prostate cancer tissues

F Qaiser, JH Trembley, S Sadiq, I Muhammad… - Molecular and cellular …, 2016 - Springer
Protein kinase CK2 plays a critical role in cell growth, proliferation, and suppression of cell
death. CK2 is overexpressed, especially in the nuclear compartment, in the majority of …

CK2 pro-survival role in prostate cancer is mediated via maintenance and promotion of androgen receptor and NFκB p65 expression

JH Trembley, BT Kren, MJ Abedin, DP Shaughnessy… - Pharmaceuticals, 2019 - mdpi.com
The prosurvival protein kinase CK2, androgen receptor (AR), and nuclear factor kappa B
(NFκB) interact in the function of prostate cells, and there is evidence of crosstalk between …

[HTML][HTML] CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: Dose and molecular mechanisms of response in xenograft …

K Ahmed, BT Kren, MJ Abedin, RI Vogel… - Oncotarget, 2016 - ncbi.nlm.nih.gov
CK2, a protein serine/threonine kinase, promotes cell proliferation and suppresses cell
death. This essential-for-survival signal demonstrates elevated expression and activity in all …

CK2 molecular targeting—tumor cell-specific delivery of RNAi in various models of cancer

JH Trembley, BT Kren, MJ Abedin, RI Vogel… - Pharmaceuticals, 2017 - mdpi.com
Protein kinase CK2 demonstrates increased protein expression relative to non-transformed
cells in the majority of cancers that have been examined. The elevated levels of CK2 are …

Therapeutic targeting of protein kinase CK2 gene expression in feline oral squamous cell carcinoma: a naturally occurring large-animal model of head and neck …

CM Cannon, JH Trembley, BT Kren… - Human Gene …, 2017 - liebertpub.com
Protein kinase CK2 (CK2) is a highly promising target for cancer therapy, and anti-CK2 gene
expression therapy has shown effectiveness in rodent models of human head and neck …

Targeting CK2 for cancer therapy using a nanomedicine approach

K Ahmed, G Unger, BT Kren, JH Trembley - Protein Kinase CK2 Cellular …, 2015 - Springer
CK2 is a signal-responsive serine/threonine protein kinase which promotes cell proliferation,
suppresses apoptosis, and demonstrates increased expression in numerous cancers. Here …