The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

The epidermis is a living, multilayered barrier with five functional levels, including a physical,
a chemical, a microbial, a neuronal, and an immune level. Altogether, this complex organ …

Summary Interleukin-23 (IL-23) and CD4+ T helper 17 (Th17) cells are thought to be critical
in psoriasis pathogenesis. Here, we report that IL-23 predominantly stimulated dermal γδ T …

Skin is a widely used route of delivery for local and systemic drugs and is potentially a route
for their delivery as nanoparticles. The skin provides a natural physical barrier against …

The skin is a unique immune organ that constitutes a complex network of physical, chemical
and microbiological barriers against external insults. Keratinocytes are the most abundant …

BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive
immune response to allergens, 2 cardinal features that are caused in part by epidermal …

The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

To provide a stable environmental barrier, the epidermis requires an integrated network of
cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the …

The skin is the largest organ of the human body and builds a barrier to protect us from the
harmful environment and also from unregulated loss of water. Keratinocytes form the skin …

Host defense peptides/proteins (HDP s), also known as antimicrobial peptides/proteins
(AMP s), are key molecules in the cutaneous innate immune system. AMP s/HDP s …