Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?
An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …
The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease
M Fang, J Wang, X Zhang, Y Geng, Z Hu, JA Rudd… - Toxicology letters, 2012 - Elsevier
The role of miR-124 on the expression of β-site APP cleaving enzyme 1 (BACE1), an
important cleavager of amyloid precursor protein that plays a pivotal role in the β-amyloid …
important cleavager of amyloid precursor protein that plays a pivotal role in the β-amyloid …
Microglia mediated neuroinflammation-signaling regulation and therapeutic considerations with special reference to some natural compounds
Y Yao, EA Ling, D Lu - 2020 - digitum.um.es
Neuroinflammation plays a central role in multiple neurodegenerative diseases and
neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) …
neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) …
[PDF][PDF] MiR-16 regulates cell death in Alzheimer's disease by targeting amyloid precursor protein.
B Zhang, CF Chen, AH Wang… - European Review for …, 2015 - europeanreview.org
OBJECTIVE: The aim of this study was to investigate the role of miR-16 in Alzheimer's
disease (AD) and to explore its mechanism of action. MATERIALS AND METHODS: A …
disease (AD) and to explore its mechanism of action. MATERIALS AND METHODS: A …
Immunophenotypic and functional characterization of eosinophil and migratory dendritic cell subsets during filarial manifestation of tropical pulmonary eosinophilia
L Ganga, P Sharma, S Tiwari, N Satoeya… - ACS infectious …, 2023 - ACS Publications
The role of eosinophil and migratory dendritic cell (migDC) subsets during tropical
pulmonary eosinophilia (TPE), a potentially fatal complication of lymphatic filariasis, has not …
pulmonary eosinophilia (TPE), a potentially fatal complication of lymphatic filariasis, has not …
Synthesis and biological evaluation of hydroxylated 3-phenylcoumarins as antioxidants and antiproliferative agents
J Yang, GY Liu, F Dai, XY Cao, Y Kang, LM Hu… - Bioorganic & medicinal …, 2011 - Elsevier
Based on the observed biological activities of coumarins and resveratrol, we synthesized
fourteen hydroxylated 3-phenylcoumarins (stilbene-coumarin hybrids) including six novel …
fourteen hydroxylated 3-phenylcoumarins (stilbene-coumarin hybrids) including six novel …
Ginkgolide B exerts cardioprotective properties against doxorubicin-induced cardiotoxicity by regulating reactive oxygen species, Akt and calcium signaling pathways …
J Gao, T Chen, D Zhao, J Zheng, Z Liu - PloS one, 2016 - journals.plos.org
The aim of this study was to evaluate the effect of Ginkgolide B (GB) on doxorubicin (DOX)
induced cardiotoxicity in vitro and in vivo. Rat cardiomyocyte cell line H9c2 was pretreated …
induced cardiotoxicity in vitro and in vivo. Rat cardiomyocyte cell line H9c2 was pretreated …
Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-γ1 signaling pathway in murine BV-2 microglial cells
Y Zong, QL Ai, LM Zhong, JN Dai… - Current medicinal …, 2012 - ingentaconnect.com
Background and Purpose: Microglial activation plays an important role in neurodegenerative
diseases by producing an array of proinflammatory enzymes and cytokines. Ginsenoside …
diseases by producing an array of proinflammatory enzymes and cytokines. Ginsenoside …
Germacrone alleviates okadaic acid-induced neurotoxicity in PC12 cells via M1 muscarinic receptor-mediated Galphaq (Gq)/phospholipase C beta (PLCβ)/protein …
M Lin, P Li, W Liu, T Niu, L Huang - Bioengineered, 2022 - Taylor & Francis
Alzheimer's disease (AD) is a neurodegenerative disorder with prominent individual
morbidity and mortality among elderly people. Germacrone (Germ) has been reported to …
morbidity and mortality among elderly people. Germacrone (Germ) has been reported to …
UCP2 upregulation promotes PLCγ‐1 signaling during skin cell transformation
A Sreedhar, J Lefort, P Petruska, X Gu… - Molecular …, 2017 - Wiley Online Library
Uncoupling protein 2 (UCP2), whose physiological role is to decrease mitochondrial
membrane potential and reactive oxygen species (ROS) production, is often overexpressed …
membrane potential and reactive oxygen species (ROS) production, is often overexpressed …