Extracellular matrix assembly: a multiscale deconstruction

JK Mouw, G Ou, VM Weaver - Nature reviews Molecular cell biology, 2014 - nature.com
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-
specific cell behaviour. The molecules that are associated with the ECM of each tissue …

[HTML][HTML] An extracellular perspective on CNS maturation: perineuronal nets and the control of plasticity

D Carulli, J Verhaagen - International Journal of Molecular Sciences, 2021 - mdpi.com
During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

The extracellular matrix of the blood–brain barrier: structural and functional roles in health, aging, and Alzheimer's disease

MJ Reed, M Damodarasamy, WA Banks - Tissue Barriers, 2019 - Taylor & Francis
There is increasing interest in defining the location, content, and role of extracellular matrix
(ECM) components in brain structure and function during development, aging, injury, and …

[HTML][HTML] The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications

Y Lei, H Han, F Yuan, A Javeed, Y Zhao - Progress in neurobiology, 2017 - Elsevier
Although neurons attract the most attention in neurobiology, our current knowledge of neural
circuit can only partially explain the neurological and psychiatric conditions of the brain …

Glioma infiltration and extracellular matrix: key players and modulators

VP Ferrer, V Moura Neto, R Mentlein - Glia, 2018 - Wiley Online Library
An outstanding characteristic of gliomas is their infiltration into brain parenchyma, a property
that impairs complete surgical resection; consequently, these tumors might recur, resulting in …

[HTML][HTML] Waste clearance in the brain

J Kaur, LM Fahmy, E Davoodi-Bojd, L Zhang… - Frontiers in …, 2021 - frontiersin.org
Waste clearance (WC) is an essential process for brain homeostasis, which is required for
the proper and healthy functioning of all cerebrovascular and parenchymal brain cells. This …

[HTML][HTML] The interstitial system of the brain in health and disease

AK Shetty, G Zanirati - Aging and disease, 2020 - ncbi.nlm.nih.gov
The brain interstitial fluid (ISF) and the cerebrospinal fluid (CSF) cushion and support the
brain cells. The ISF occupies the brain interstitial system (ISS), whereas the CSF fills the …

[HTML][HTML] Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues

GN Kouzehgarani, T Feldsien, HH Engelhard… - Advanced Drug Delivery …, 2021 - Elsevier
Initially thought to be useful only to reach tissues in the immediate vicinity of the CSF
circulatory system, CSF circulation is now increasingly viewed as a viable pathway to deliver …

Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair

ER Burnside, EJ Bradbury - Neuropathology and applied …, 2014 - Wiley Online Library
Brain and spinal cord injury can result in permanent cognitive, motor, sensory and
autonomic deficits. The central nervous system (CNS) has a poor intrinsic capacity for …

[HTML][HTML] Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson's disease: a systematic review

WA Rike, S Stern - International Journal of Molecular Sciences, 2023 - mdpi.com
The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …