Endothelial deficiency of insulin‐like growth factor‐1 receptor leads to blood–brain barrier disruption and accelerated endothelial senescence in mice, mimicking …
Introduction Age‐related blood–brain barrier (BBB) disruption, cerebromicrovascular
senescence, and microvascular rarefaction substantially contribute to the pathogenesis of …
senescence, and microvascular rarefaction substantially contribute to the pathogenesis of …
[HTML][HTML] Acute neuroendocrine changes after traumatic brain injury
ZD Magyar-Sumegi, L Stankovics, D Lendvai-Emmert… - Brain and spine, 2024 - Elsevier
Introduction Post-traumatic hypopituitarism (PTHP) is a significant, but often neglected
consequence of traumatic brain injury (TBI). Research question We aimed to provide a …
consequence of traumatic brain injury (TBI). Research question We aimed to provide a …
Pathological epigenetic events and reversibility review: the intersection between hallmarks of aging and developmental origin of health and disease
DM Ruden, A Singh, DA Rappolee - Epigenomics, 2023 - Future Medicine
We discuss pathological epigenetic events that are reversible (PEERs). A recent study by
Poganik and colleagues showed that severe stress in mice and humans transiently elevates …
Poganik and colleagues showed that severe stress in mice and humans transiently elevates …
Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged …
Age-related cerebromicrovascular changes, including blood-brain barrier (BBB) disruption
and microvascular rarefaction, play a significant role in the development of vascular …
and microvascular rarefaction, play a significant role in the development of vascular …
Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1
MA Bickel, DM Sherry, EC Bullen, ML Vance… - Microvascular …, 2024 - Elsevier
Objective Vascular smooth muscle cell (VSMC) phenotypic switching is critical for normal
vessel formation, vascular stability, and healthy brain aging. Phenotypic switching is …
vessel formation, vascular stability, and healthy brain aging. Phenotypic switching is …
IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
LR Miller, MA Bickel, S Tarantini, ME Runion… - Frontiers in Aging …, 2024 - frontiersin.org
Introduction Cerebrovascular pathologies contribute to cognitive decline during aging,
leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin …
leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin …
Vascular smooth muscle cell-specific Igf1r deficiency exacerbates the development of hypertension-induced cerebral microhemorrhages and gait defects
LR Miller, MA Bickel, ML Vance, H Vaden, D Nagykaldi… - GeroScience, 2024 - Springer
Cerebrovascular fragility and cerebral microhemorrhages (CMH) contribute to age-related
cognitive impairment, mobility defects, and vascular cognitive impairment and dementia …
cognitive impairment, mobility defects, and vascular cognitive impairment and dementia …
Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood …
Age-related impairment of neurovascular coupling (NVC;“functional hyperemia”) is a critical
factor in the development of vascular cognitive impairment (VCI). Recent geroscience …
factor in the development of vascular cognitive impairment (VCI). Recent geroscience …
Impact of visceral adipose tissue on longevity and metabolic health: a comparative study of gene expression in perirenal and epididymal fat of Ames dwarf mice
A Zaczek, A Lewiński, M Karbownik-Lewińska… - GeroScience, 2024 - Springer
Emerging research underscores the pivotal role of adipose tissue in regulating systemic
aging processes, particularly when viewed through the lens of the endocrine hypotheses of …
aging processes, particularly when viewed through the lens of the endocrine hypotheses of …
[HTML][HTML] Linking peripheral atherosclerosis to blood–brain barrier disruption: elucidating its role as a manifestation of cerebral small vessel disease in vascular …
Aging plays a pivotal role in the pathogenesis of cerebral small vessel disease (CSVD),
contributing to the onset and progression of vascular cognitive impairment and dementia …
contributing to the onset and progression of vascular cognitive impairment and dementia …