Background/Aims: Recently, loss-of-function mutations in the MKRN3 gene have been
implicated in the etiology of familial central precocious puberty (CPP) in both sexes. We …

The initiation of puberty is driven by an upsurge in hypothalamic gonadotropin-releasing
hormone (GnRH) secretion. In turn, GnRH secretion upsurge depends on the development …

Kisspeptin (encoded by KISS1) is a crucial activator of reproductive function. The role of
kisspeptin has been studied extensively within the hypothalamus but little is known about its …

Context: Epidemiological evidence on maternal and paternal heritability of the wide normal
variation within pubertal timing is sparse. Objective: We aimed to estimate the impact of …

The factors that trigger human puberty are among the central mysteries of reproductive
biology. Several approaches, including mutational analysis of candidate genes, large-scale …

Puberty is initiated by gonadotropin-releasing hormone from the hypothalamus followed by
a complex sequence of endocrine changes and is regulated by both genetic and …

The Notch signaling pathway is highly conserved during evolution. It has been well
documented that Notch signaling regulates cell proliferation, migration, and death in the …

Telocytes (TCs) have been described in various organs and species (www. telocytes. com)
as cells with telopodes (Tps)–very long cellular extensions with an alternation of thin …

Context: Central precocious puberty (CPP), defined as the development of secondary sex
characteristics prior to age 8 years in girls and 9 years in boys, results from the premature …

The timing of puberty has considerable biological, psychosocial and long-term health
implications. Secular trends in age at pubertal development, the effects of obesity and the …