Objective To evaluate the characteristics and significance of serum kisspeptin and makorin
ring finger protein 3 (MKRN3) levels for the diagnosis of central precocious puberty (CPP) in …

Background Pubertal timing is known to be influenced by interactions among various
genetic, nutritional, environmental and socio-economic factors, although the ultimate …

The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its
function as a neuropeptide involved in diverse physiologic processes is more well studied …

This chapter begins with a basic science update on the development of the female
reproductive system. This starts with sections on maturation of the neuroendocrine-ovarian …

Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as
gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are …

Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The onset of puberty is …

Gonadotrophin dependent sexual precocity, commonly referred to as central precocious
puberty (CPP), results from a premature reactivation of the hypothalamic-pituitary-gonadal …

Loss-of-function mutations in the gene encoding the makorin RING finger protein 3 (MKRN3)
have recently been reported to underlie familial cases of central precocious puberty (CPP) …

Understanding the regulation of puberty timing has relevance to developmental and human
biology and to the pathogenesis of various diseases. Recent large-scale genome-wide …

The emergence of kisspeptin as a crucial regulator of the hypothalamo-pituitary-gonadal
(HPG) axis over the last 14 years has answered many questions as to the control of …