KiSS-1, first identified as an anti-metastasis gene in melanoma, encodes C-terminally
amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14 …

В книге рассматриваются современные взгляды о роли генетических, эндокринных и
иммунологических факторов в патогенезе генитального эндометриоза, обсуждаются …

The goal of this study was to investigate how the Arg386Pro mutation prolongs KiSS-1
receptor (KISS1R) responsiveness to kisspeptin, contributing to human central precocious …

The timing of pubertal development is strongly influenced by the genetic background, and
clinical presentations of delayed puberty are often found within families with clear patterns of …

Background: The control of male fertility requires accurate endocrine, paracrine and
autocrine communications along the hypothalamus-pituitary-gonad (HPG) axis. In this …

STUDY QUESTION Is there an (epi) genetic basis in patients with central precocious puberty
(CPP) associated with multiple anomalies that unmasks underlying mechanisms or reveals …

OBJECTIVE: To investigate the presence of variants in the TAC3 and TACR3 genes, which
encode NKB and its receptor (NK3R), respectively, in a large cohort of patients with …

Makorin ring finger protein 3 (MKRN3) is an important neuroendocrine player in the control
of pubertal timing and upstream inhibitor of gonadotropin-releasing hormone secretion. In …

Background Childhood obesity has important effects on the onset and development of
puberty. Although a number of studies have confirmed the relationship between obesity and …

Central precocious puberty may be familial in about a quarter of the idiopathic cases.
However, little is known about the genetic causes responsible for the disorder. In this report …