Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular
matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically …

Cellular senescence is a biological process by which cells lose their capacity to proliferate
yet remain metabolically active. Although originally considered a protective mechanism to …

Mechanisms underlying the pathogenesis of pulmonary fibrosis remain incompletely
understood. Emerging evidence suggests changes in mitochondrial quality control are a …

Tissue stem cells undergo premature senescence under stress, promoting age-related
diseases; however, the associated mechanisms remain unclear. Here, we report that in …

Rationale: A prevailing paradigm recognizes idiopathic pulmonary fibrosis (IPF) originating
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …

The lung is often overlooked as a metabolically active organ, yet biochemical studies have
long demonstrated that glucose utilization surpasses that of many other organs, including …

Pulmonary fibrosis is a chronic, progressive, incurable interstitial lung disease with high
mortality after diagnosis and remains a global public health problem. Despite advances and …

Lung diseases are a major global health problem, affecting millions of people worldwide.
Recent research has highlighted the critical role that mitochondrial quality control plays in …

Epithelial cell dysfunction has emerged as a central component of the pathophysiology of
diffuse parenchymal diseases including idiopathic pulmonary fibrosis (IPF). Alveolar type 2 …

Deiodinases modify the biological activity of thyroid hormone (TH) molecules, ie, they may
activate thyroxine (T4) to 3, 5, 3′-triiodothyronine (T3), or they may inactivate T3 to 3, 3 …