Pulmonary senescence is accelerated by unresolved DNA damage response, underpinning
susceptibility to pulmonary fibrosis. Recently it was reported that the SARS-Cov-2 viral …

Pulmonary fibrosis is a devastating disease characterized by accumulation of activated
fibroblasts and scarring in the lung. While fibroblast activation in physiological wound repair …

Tissue stem cell exhaustion is a key hallmark of aging, and in this study, we characterised its
manifestation in the distal lung. We compared the lungs of 3-and 22-month old mice. We …

Idiopathic pulmonary fibrosis (IPF), the scarring of lung parenchyma resulting in the loss of
lung function, remains a fatal disease with a significant unmet medical need. Patients with …

Fibrosis is defined by abnormal accumulation of extracellular matrix, which can affect
virtually every organ system under diseased conditions. Fibrotic tissue remodeling often …

Tissue fibrosis is a chronic disease driven by persistent fibroblast activation that has recently
been linked to epigenetic modifications. Here, we screened a small library of epigenetic …

Idiopathic pulmonary fibrosis is a fatal age-related lung disease characterised by
progressive and irreversible scarring of the lung. Although the details are not fully …

Type II alveolar epithelial cell (AECII) apoptosis is one of the most vital causes of sepsis‐
induced acute respiratory distress syndrome (ARDS). Recent evidence has proved that …

Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in
telomere maintenance leading to very short telomeres and the premature onset of certain …

Background Nintedanib represents an antifibrotic compound able to slow down disease
progression of patients with idiopathic pulmonary fibrosis (IPF). Objective To investigate the …