Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Isoniazid (INH) was the first synthesized drug that mediated bactericidal killing of the
bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH …

The central pathogen-immune interface in tuberculosis is the granuloma, a complex host
immune structure that dictates infection trajectory and physiology. Granuloma macrophages …

One billion people worldwide are affected by fungal pathogens, of which 1.6 million
succumb to fungal infections per year. This review discusses the emergence and evolution …

Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress,
where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome …

Stochastic formation of Mycobacterium tuberculosis (Mtb) persisters achieves a high level of
antibiotic-tolerance and serves as a source of multidrug-resistant (MDR) mutations. As …

Bacterial nutrition is an essential aspect of host–pathogen interaction. For the intracellular
pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans …

While the existence of a special relationship between Mycobacterium tuberculosis (Mtb) and
host lipids has long been known, it remains a challenging enigma. It was clearly established …

Different effector arms of the immune system are optimized to protect from different classes
of pathogens. In some cases, pathogens manipulate the host immune system to promote the …

Nitrogen metabolism of Mycobacterium tuberculosis (Mtb) is crucial for the survival of this
important pathogen in its primary human host cell, the macrophage, but little is known about …