Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses
Polymeric materials have been extensively developed as a delivery vehicle for nucleic acids
over the past two decades. Many previous studies have demonstrated that synthetic delivery …
over the past two decades. Many previous studies have demonstrated that synthetic delivery …
HPMA copolymers: origins, early developments, present, and future
J Kopeček, P Kopečková - Advanced drug delivery reviews, 2010 - Elsevier
The overview covers the discovery of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers, initial studies on their synthesis, evaluation of biological properties, and …
copolymers, initial studies on their synthesis, evaluation of biological properties, and …
Polymer–drug conjugates: Origins, progress to date and future directions
J Kopeček - Advanced drug delivery reviews, 2013 - Elsevier
This overview focuses on bioconjugates of water-soluble polymers with low molecular
weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the …
weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the …
Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics
Synthetic methods in polymer chemistry have evolved tremendously during the last decade.
Nowadays more and more attention is devoted to the application of those tools in the …
Nowadays more and more attention is devoted to the application of those tools in the …
Advances in multiple stimuli-responsive drug-delivery systems for cancer therapy
R Jia, L Teng, L Gao, T Su, L Fu, Z Qiu… - International journal of …, 2021 - Taylor & Francis
Nanomedicines afford unique advantages in therapeutic intervention against tumors.
However, conventional nanomedicines have failed to achieve the desired effect against …
However, conventional nanomedicines have failed to achieve the desired effect against …
Multistage nanovehicle delivery system based on stepwise size reduction and charge reversal for programmed nuclear targeting of systemically administered …
L Li, W Sun, J Zhong, Q Yang, X Zhu… - Advanced Functional …, 2015 - Wiley Online Library
The nucleus is the final target of many first‐line chemotherapeutics, but the need to
overcome multiple physiological barriers imposes conflicting requirements for size and …
overcome multiple physiological barriers imposes conflicting requirements for size and …
Bioreducible fluorinated peptide dendrimers capable of circumventing various physiological barriers for highly efficient and safe gene delivery
X Cai, R Jin, J Wang, D Yue, Q Jiang… - ACS Applied Materials …, 2016 - ACS Publications
Polymeric vectors have shown great promise in the development of safe and efficient gene
delivery systems; however, only a few have been developed in clinical settings due to poor …
delivery systems; however, only a few have been developed in clinical settings due to poor …
Endosomal pH-Activatable Poly(ethylene oxide)-graft-Doxorubicin Prodrugs: Synthesis, Drug Release, and Biodistribution in Tumor-Bearing Mice
L Zhou, R Cheng, H Tao, S Ma, W Guo… - …, 2011 - ACS Publications
Novel poly (ethylene oxide)-graft-doxorubicin (PEO-g-DOX) prodrugs with DOX covalently
conjugated to PEO via a pH-sensitive hydrazone bond were developed. PEO-g-DOX …
conjugated to PEO via a pH-sensitive hydrazone bond were developed. PEO-g-DOX …
In vitro cytotoxicity of RAFT polymers
D Pissuwan, C Boyer, K Gunasekaran… - …, 2010 - ACS Publications
The RAFT technique has been increasingly used to generate polymers for potential
biological applications. However, to-date, the toxicity of the RAFT-polymers has received …
biological applications. However, to-date, the toxicity of the RAFT-polymers has received …