Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Melanoma is the most lethal type of skin cancer, originating from the malignant
transformation of melanocyte. While the development of targeted therapy and …

Sirtuins and autophagy are well‐characterized agents that can promote longevity and
protect individual organisms from age‐associated diseases like neurodegenerative …

Dysregulated glycolysis has been noted in several pathological processes characterized by
supporting cell proliferation. Nonetheless, the role of glycolysis reprogramming is not well …

Background Androgen deprivation therapy (ADT) is the backbone of therapy for advanced
prostate cancer (PCa). Despite the good initial response, castration resistance and …