Pathogenesis of Crohn's perianal fistula—understanding factors impacting on success and failure of treatment strategies

PJ Tozer, P Lung, AJ Lobo, S Sebastian… - Alimentary …, 2018 - Wiley Online Library
Background Evidence from groups who have studied fistula aetiology and extrapolation from
interventional studies supports a multifactorial hypothesis of Crohn's perianal fistula, with …

Preclinical model of perianal fistulizing Crohn's disease

M Flacs, M Collard, S Doblas, M Zappa… - Inflammatory Bowel …, 2020 - academic.oup.com
Abstract Background Fistulizing anoperineal lesions (FAPLs) are common and severe
complications of Crohn's disease (CD), exposing patients to the risk of anal sphincter …

A Preclinical Validation of Iron Oxide Nanoparticles for Treatment of Perianal Fistulizing Crohn's Disease

A Cazelles, MK Collard, Y Lalatonne, S Doblas… - International Journal of …, 2022 - mdpi.com
Fistulizing anoperineal lesions are severe complications of Crohn's disease (CD) that affect
quality of life with a long-term risk of anal sphincter destruction, incontinence, permanent …

Effectiveness of the Aloe Vera extract in the treatment of fistula-in-ano

AL Cavasana, CHM dos Santos… - Journal of …, 2020 - thieme-connect.com
Rationale Considering that anal fistulae are still challenging regarding their treatment due to
the risk of fecal incontinence in the most complex cases and the increasing use of …

Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract

BC Comparin, CHM dos Santos… - Journal of …, 2018 - thieme-connect.com
Rationale There is a need for a low cost treatment for complex anal fistulas that can heal
without causing fecal incontinence, with room for the study of herbal medicines. Objective To …

Establishment of a novel experimental model of infected anal fistula in rat

M Zhao, A Wang, L Zhang, H Yu - Laboratory Animal Research, 2022 - Springer
Refractory Crohn's-like enterocutaneous fistula indicates the aggressive manifestation and
lead to poor prognosis of patients. The development of multidisciplinary strategies for fistula …

Primary sphincteroplasty comparing two different stitches in anal fistula treatment: experimental study in rats

OAV Tanus, CHM SANTOS, DM Dourado… - … Brasileiros de Cirurgia …, 2019 - SciELO Brasil
Background: Anal fistula is by definition the communication between the rectum or anal
canal with the perineal region, which may be epithelialized and has cryptoglandular origin in …

[HTML][HTML] Experimental porcine model of complex fistula-in-ano

AB Ma-Mu-Ti-Jiang, H Chen, X Liu… - World Journal of …, 2017 - ncbi.nlm.nih.gov
METHODS Twelve healthy pigs were randomly divided into two groups. Under general
anesthesia, the experimental group underwent rubber band ligation surgery, and the control …

[HTML][HTML] Efficacy of low-level laser therapy on fistula-in-ano treatment

CHM Santos, FDS Guimarães, FHR Barros… - … Brasileiros de Cirurgia …, 2021 - SciELO Brasil
SciELO - Brasil - EFFICACY OF LOW-LEVEL LASER THERAPY ON FISTULA-IN-ANO
TREATMENT EFFICACY OF LOW-LEVEL LASER THERAPY ON FISTULA-IN-ANO TREATMENT …

[HTML][HTML] Esfincteroplastia primária comparando dois diferentes fios no tratamento da fístula anal: estudo experimental em ratos

OAV TANUS, CHM SANTOS… - … Brasileiros de Cirurgia …, 2019 - SciELO Brasil
Background: Anal fistula is by definition the communication between the rectum or anal
canal with the perineal region, which may be epithelialized and has cryptoglandular origin in …