Revisiting the neurovascular unit

S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

F Leng, P Edison - Nature Reviews Neurology, 2021 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

[HTML][HTML] Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale

N Renaudin, C Demené, A Dizeux, N Ialy-Radio… - Nature …, 2022 - nature.com
The advent of neuroimaging has increased our understanding of brain function. While most
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …

[HTML][HTML] Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

E Császár, N Lénárt, C Cserép, Z Környei… - Journal of Experimental …, 2022 - rupress.org
Disclosures: D. Máthé reported grants from European Union H2020 HCEMM-739593 and
from NRDIO, Hungary, TKP-BIOImaging-2020-4.1. 1-TKP2020 during the conduct of the …

[HTML][HTML] Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

[HTML][HTML] Pericyte control of blood flow across microvascular zones in the central nervous system

DA Hartmann, V Coelho-Santos… - Annual review of …, 2022 - annualreviews.org
The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

[HTML][HTML] The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease

C Iadecola - Neuron, 2017 - cell.com
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

The emerging nature of astrocyte diversity

BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

Absorption, distribution, and toxicity of per-and polyfluoroalkyl substances (PFAS) in the brain: a review

Y Cao, C Ng - Environmental Science: Processes & Impacts, 2021 - pubs.rsc.org
Per-and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals colloquially
known as “forever chemicals” because of their high persistence. PFAS have been detected …