Role of m6A RNA methylation in cardiovascular disease
Y Qin, L Li, E Luo, J Hou, G Yan… - International …, 2020 - spandidos-publications.com
Abstract N6‑methyladenosine (m6A) is the most prevalent and abundant type of internal post‑
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …
mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification
Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …
RNA epitranscriptomic modification and controls multiple cellular functions during …
N6-adenosine methylation (m6A): a promising new molecular target in hypertension and cardiovascular diseases
A Paramasivam, J Vijayashree Priyadharsini… - Hypertension …, 2020 - nature.com
To the Editor: Epitranscriptomics is an emerging field of biology, in which post-transcriptional
modifications of RNA, as a novel mechanism discovered recently, are suggested to be a vital …
modifications of RNA, as a novel mechanism discovered recently, are suggested to be a vital …
DirectRMDB: a database of post-transcriptional RNA modifications unveiled from direct RNA sequencing technology
With advanced technologies to map RNA modifications, our understanding of them has
been revolutionized, and they are seen to be far more widespread and important than …
been revolutionized, and they are seen to be far more widespread and important than …
Changes in m6A RNA methylation contribute to heart failure progression by modulating translation
T Berulava, E Buchholz, V Elerdashvili… - European journal of …, 2020 - Wiley Online Library
Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …
METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury
L Wang, J Wang, P Yu, J Feng, G Xu, X Zhao… - Nature …, 2022 - nature.com
RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …
to various pathophysiological processes. Although the benefit of regular exercise on the …
METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner
R Zhang, Y Qu, Z Ji, C Hao, Y Su, Y Yao, W Zuo… - Cellular & molecular …, 2022 - Springer
Background METTL3 is the core catalytic enzyme in m6A and is involved in a variety of
cardiovascular diseases. However, whether and how METTL3 plays a role during …
cardiovascular diseases. However, whether and how METTL3 plays a role during …
RNA modification: mechanisms and therapeutic targets
L Qiu, Q Jing, Y Li, J Han - Molecular Biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …
that are regulated by specific modifying enzymes. They play important roles in the regulation …
m6A methylation in cardiovascular diseases: from mechanisms to therapeutic potential
L Li, N Xu, J Liu, Z Chen, X Liu, J Wang - Frontiers in genetics, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide.
Recent studies have shown that n6-methyladenosine (m6A) plays a major role in …
Recent studies have shown that n6-methyladenosine (m6A) plays a major role in …
RNA modifications in cardiovascular health and disease
RNA is not always a faithful copy of DNA. Advances in tools enabling the interrogation of the
exact RNA sequence have permitted revision of how genetic information is transferred. We …
exact RNA sequence have permitted revision of how genetic information is transferred. We …