Role of m6A RNA methylation in cardiovascular disease

Y Qin, L Li, E Luo, J Hou, G Yan… - International …, 2020 - spandidos-publications.com
Abstract N6‑methyladenosine (m6A) is the most prevalent and abundant type of internal post‑
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …

mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification

R Kumari, P Ranjan, ZG Suleiman… - Cardiovascular …, 2022 - academic.oup.com
Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …

N6-adenosine methylation (m6A): a promising new molecular target in hypertension and cardiovascular diseases

A Paramasivam, J Vijayashree Priyadharsini… - Hypertension …, 2020 - nature.com
To the Editor: Epitranscriptomics is an emerging field of biology, in which post-transcriptional
modifications of RNA, as a novel mechanism discovered recently, are suggested to be a vital …

DirectRMDB: a database of post-transcriptional RNA modifications unveiled from direct RNA sequencing technology

Y Zhang, J Jiang, J Ma, Z Wei, Y Wang… - Nucleic Acids …, 2023 - academic.oup.com
With advanced technologies to map RNA modifications, our understanding of them has
been revolutionized, and they are seen to be far more widespread and important than …

Changes in m6A RNA methylation contribute to heart failure progression by modulating translation

T Berulava, E Buchholz, V Elerdashvili… - European journal of …, 2020 - Wiley Online Library
Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

L Wang, J Wang, P Yu, J Feng, G Xu, X Zhao… - Nature …, 2022 - nature.com
RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …

METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

R Zhang, Y Qu, Z Ji, C Hao, Y Su, Y Yao, W Zuo… - Cellular & molecular …, 2022 - Springer
Background METTL3 is the core catalytic enzyme in m6A and is involved in a variety of
cardiovascular diseases. However, whether and how METTL3 plays a role during …

RNA modification: mechanisms and therapeutic targets

L Qiu, Q Jing, Y Li, J Han - Molecular Biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

m6A methylation in cardiovascular diseases: from mechanisms to therapeutic potential

L Li, N Xu, J Liu, Z Chen, X Liu, J Wang - Frontiers in genetics, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide.
Recent studies have shown that n6-methyladenosine (m6A) plays a major role in …

RNA modifications in cardiovascular health and disease

A Gatsiou, K Stellos - Nature Reviews Cardiology, 2023 - nature.com
RNA is not always a faithful copy of DNA. Advances in tools enabling the interrogation of the
exact RNA sequence have permitted revision of how genetic information is transferred. We …