The authors of this review both served on the National Academy of Science, Engineering,
and Medicine Committee that produced the report,“Social Isolation and Loneliness in Older …

Loneliness is associated with increased morbidity and mortality. Deeper understanding of
neurobiological mechanisms underlying loneliness is needed to identify potential …

Social isolation and loneliness are serious yet underappreciated public health risks that
affect a significant portion of the older adult population. Approximately one-quarter of …

There is growing evidence that loneliness is associated with mild cognitive impairment (MCI)
and dementia. However, the extent of this association remains unclear. A systematic review …

Objective This study aimed to examine the association of loneliness and social isolation on
cognition over a 3‐year follow‐up period in middle‐and older‐aged adults. Methods Data …

Objectives To examine the effect of perceived loneliness on the development of dementia
(all-cause), Alzheimer´ s disease (AD), and vascular dementia (VaD). Method The study …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Objective: To understand the role of depressive symptoms in preclinical Alzheimer's
disease, it is essential to define their temporal relationship to Alzheimer's proteinopathies in …

Objectives Social relationships are important for the maintenance of cognitive function at
older ages, with both objective features of social networks and perceived social connections …

Loneliness and social isolation are strongly associated with several adverse health
outcomes in older persons including death and functional impairments. The strength of …